Late-stage (radio)fluorination of alkyl phosphonates via electrophilic activation
Late-stage (radio)fluorination of alkyl phosphonates via electrophilic activation
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London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Constructing organic fluorophosphines, vital drug skeletons, through the direct fluorination of readily available alkyl phosphonates has been impeded due to the intrinsic low electrophilicity of P
V
and the high bond energy of P═O bond. Here, alkyl phosphonates are electrophilically activated with triflic anhydride and
N
-heteroaromatic...
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Full title
Late-stage (radio)fluorination of alkyl phosphonates via electrophilic activation
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TN_cdi_doaj_primary_oai_doaj_org_article_e55ef7532be74ee5b23751fc770d5d59
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_e55ef7532be74ee5b23751fc770d5d59
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-024-54208-y
