Targeting of RRM2 suppresses DNA damage response and activates apoptosis in atypical teratoid rhabdo...
Targeting of RRM2 suppresses DNA damage response and activates apoptosis in atypical teratoid rhabdoid tumor
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Publisher
England: BioMed Central Ltd
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Language
English
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Publisher
England: BioMed Central Ltd
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Atypical teratoid rhabdoid tumors (ATRT) is a rare but aggressive malignancy in the central nervous system, predominantly occurring in early childhood. Despite aggressive treatment, the prognosis of ATRT patients remains poor. RRM2, a subunit of ribonucleotide reductase, has been reported as a biomarker for aggressiveness and poor prognostic condit...
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Full title
Targeting of RRM2 suppresses DNA damage response and activates apoptosis in atypical teratoid rhabdoid tumor
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TN_cdi_doaj_primary_oai_doaj_org_article_e574275cddf349a6bfdc6e8be6ff72fb
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_e574275cddf349a6bfdc6e8be6ff72fb
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ISSN
1756-9966,0392-9078
E-ISSN
1756-9966
DOI
10.1186/s13046-023-02911-x
