A Modelling Framework Linking Resource-Based Stochastic Translation to the Optimal Design of Synthet...
A Modelling Framework Linking Resource-Based Stochastic Translation to the Optimal Design of Synthetic Constructs
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Switzerland: MDPI AG
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English
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Switzerland: MDPI AG
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The effect of gene expression burden on engineered cells has motivated the use of "whole-cell models" (WCMs) that use shared cellular resources to predict how unnatural gene expression affects cell growth. A common problem with many WCMs is their inability to capture translation in sufficient detail to consider the impact of ribosomal queue formati...
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A Modelling Framework Linking Resource-Based Stochastic Translation to the Optimal Design of Synthetic Constructs
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TN_cdi_doaj_primary_oai_doaj_org_article_e574ddd44b36458fbe6f933b7f241ff9
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_e574ddd44b36458fbe6f933b7f241ff9
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ISSN
2079-7737
E-ISSN
2079-7737
DOI
10.3390/biology10010037
