Diabetes causes marked inhibition of mitochondrial metabolism in pancreatic β-cells
Diabetes causes marked inhibition of mitochondrial metabolism in pancreatic β-cells
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Author / Creator
Haythorne, Elizabeth , Rohm, Maria , van de Bunt, Martijn , Brereton, Melissa F. , Tarasov, Andrei I. , Blacker, Thomas S. , Sachse, Gregor , Silva dos Santos, Mariana , Terron Exposito, Raul , Davis, Simon , Baba, Otto , Fischer, Roman , Duchen, Michael R. , Rorsman, Patrik , MacRae, James I. and Ashcroft, Frances M.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Diabetes is a global health problem caused primarily by the inability of pancreatic β-cells to secrete adequate levels of insulin. The molecular mechanisms underlying the progressive failure of β-cells to respond to glucose in type-2 diabetes remain unresolved. Using a combination of transcriptomics and proteomics, we find significant dysregulation...
Alternative Titles
Full title
Diabetes causes marked inhibition of mitochondrial metabolism in pancreatic β-cells
Authors, Artists and Contributors
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_e58a88780c484df287e145eadffc1041
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_e58a88780c484df287e145eadffc1041
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-10189-x
