Functional cross-talk between allosteric effects of activating and inhibiting ligands underlies PKM2...
Functional cross-talk between allosteric effects of activating and inhibiting ligands underlies PKM2 regulation
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Publisher
England: eLife Sciences Publications Ltd
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Language
English
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Publisher
England: eLife Sciences Publications Ltd
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Contents
Several enzymes can simultaneously interact with multiple intracellular metabolites, however, how the allosteric effects of distinct ligands are integrated to coordinately control enzymatic activity remains poorly understood. We addressed this question using, as a model system, the glycolytic enzyme pyruvate kinase M2 (PKM2). We show that the PKM2...
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Full title
Functional cross-talk between allosteric effects of activating and inhibiting ligands underlies PKM2 regulation
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TN_cdi_doaj_primary_oai_doaj_org_article_e58bac1bbbec4b70ba28e24697d45179
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_e58bac1bbbec4b70ba28e24697d45179
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.45068
