A phase transition enhances the catalytic activity of SARM1, an NAD+ glycohydrolase involved in neur...
A phase transition enhances the catalytic activity of SARM1, an NAD+ glycohydrolase involved in neurodegeneration
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Publisher
England: eLife Sciences Publications Ltd
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Language
English
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Publisher
England: eLife Sciences Publications Ltd
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Scope and Contents
Contents
Sterile alpha and toll/interleukin receptor (TIR) motif–containing protein 1 (SARM1) is a neuronally expressed NAD
+
glycohydrolase whose activity is increased in response to stress. NAD
+
depletion triggers axonal degeneration, which is a characteristic feature of neurological diseases. Notably, loss of SARM1 is protective in murine mo...
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Full title
A phase transition enhances the catalytic activity of SARM1, an NAD+ glycohydrolase involved in neurodegeneration
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TN_cdi_doaj_primary_oai_doaj_org_article_e5b3cc6dff2e4f6c86a6d52fc02ac50e
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_e5b3cc6dff2e4f6c86a6d52fc02ac50e
Other Identifiers
ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.66694
