Efficient clofilium tosylate-mediated rescue of POLG-related disease phenotypes in zebrafish
Efficient clofilium tosylate-mediated rescue of POLG-related disease phenotypes in zebrafish
About this item
Full title
Author / Creator
Facchinello, Nicola , Laquatra, Claudio , Locatello, Lisa , Beffagna, Giorgia , Brañas Casas, Raquel , Fornetto, Chiara , Dinarello, Alberto , Martorano, Laura , Vettori, Andrea , Risato, Giovanni , Celeghin, Rudy , Meneghetti, Giacomo , Santoro, Massimo Mattia , Delahodde, Agnes , Vanzi, Francesco , Rasola, Andrea , Dalla Valle, Luisa , Rasotto, Maria Berica , Lodi, Tiziana , Baruffini, Enrico , Argenton, Francesco and Tiso, Natascia
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
The DNA polymerase gamma (Polg) is a nuclear-encoded enzyme involved in DNA replication in animal mitochondria. In humans, mutations in the
POLG
gene underlie a set of mitochondrial diseases characterized by mitochondrial DNA (mtDNA) depletion or deletion and multiorgan defects, named POLG disorders, for which an effective therapy is still ne...
Alternative Titles
Full title
Efficient clofilium tosylate-mediated rescue of POLG-related disease phenotypes in zebrafish
Authors, Artists and Contributors
Author / Creator
Laquatra, Claudio
Locatello, Lisa
Beffagna, Giorgia
Brañas Casas, Raquel
Fornetto, Chiara
Dinarello, Alberto
Martorano, Laura
Vettori, Andrea
Risato, Giovanni
Celeghin, Rudy
Meneghetti, Giacomo
Santoro, Massimo Mattia
Delahodde, Agnes
Vanzi, Francesco
Rasola, Andrea
Dalla Valle, Luisa
Rasotto, Maria Berica
Lodi, Tiziana
Baruffini, Enrico
Argenton, Francesco
Tiso, Natascia
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_e5b4a8a5e87b4483a23748afb74ea087
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_e5b4a8a5e87b4483a23748afb74ea087
Other Identifiers
ISSN
2041-4889
E-ISSN
2041-4889
DOI
10.1038/s41419-020-03359-z
