Targeting posttranslational modifications of RIOK1 inhibits the progression of colorectal and gastri...
Targeting posttranslational modifications of RIOK1 inhibits the progression of colorectal and gastric cancers
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England: eLife Science Publications, Ltd
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English
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England: eLife Science Publications, Ltd
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RIOK1 has recently been shown to play important roles in cancers, but its posttranslational regulation is largely unknown. Here we report that RIOK1 is methylated at K411 by SETD7 methyltransferase and that lysine-specific demethylase 1 (LSD1) reverses its methylation. The mutated RIOK1 (K411R) that cannot be methylated exhibits a longer half-life...
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Targeting posttranslational modifications of RIOK1 inhibits the progression of colorectal and gastric cancers
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TN_cdi_doaj_primary_oai_doaj_org_article_e5d3e367fa1b4ad5ade7856df54141ac
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_e5d3e367fa1b4ad5ade7856df54141ac
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2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.29511
