Critical role of the HDAC6–cortactin axis in human megakaryocyte maturation leading to a proplatelet...
Critical role of the HDAC6–cortactin axis in human megakaryocyte maturation leading to a proplatelet-formation defect
About this item
Full title
Author / Creator
Messaoudi, Kahia , Ali, Ashfaq , Ishaq, Rameez , Palazzo, Alberta , Sliwa, Dominika , Bluteau, Olivier , Souquère, Sylvie , Muller, Delphine , Diop, Khadija M. , Rameau, Philippe , Lapierre, Valérie , Marolleau, Jean-Pierre , Matthias, Patrick , Godin, Isabelle , Pierron, Gérard , Thomas, Steven G. , Watson, Stephen P. , Droin, Nathalie , Vainchenker, William , Plo, Isabelle , Raslova, Hana and Debili, Najet
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
Thrombocytopenia is a major side effect of a new class of anticancer agents that target histone deacetylase (HDAC). Their mechanism is poorly understood. Here, we show that HDAC6 inhibition and genetic knockdown lead to a strong decrease in human proplatelet formation (PPF). Unexpectedly, HDAC6 inhibition-induced tubulin hyperacetylation has no eff...
Alternative Titles
Full title
Critical role of the HDAC6–cortactin axis in human megakaryocyte maturation leading to a proplatelet-formation defect
Authors, Artists and Contributors
Author / Creator
Ali, Ashfaq
Ishaq, Rameez
Palazzo, Alberta
Sliwa, Dominika
Bluteau, Olivier
Souquère, Sylvie
Muller, Delphine
Diop, Khadija M.
Rameau, Philippe
Lapierre, Valérie
Marolleau, Jean-Pierre
Matthias, Patrick
Godin, Isabelle
Pierron, Gérard
Thomas, Steven G.
Watson, Stephen P.
Droin, Nathalie
Vainchenker, William
Plo, Isabelle
Raslova, Hana
Debili, Najet
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_e6244d22664d4e168a0d548e8a713d18
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_e6244d22664d4e168a0d548e8a713d18
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-017-01690-2
