Paracrine control of α-cell glucagon exocytosis is compromised in human type-2 diabetes
Paracrine control of α-cell glucagon exocytosis is compromised in human type-2 diabetes
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London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Glucagon is released from pancreatic α-cells to activate pathways that raise blood glucose. Its secretion is regulated by α-cell-intrinsic glucose sensing and paracrine control through insulin and somatostatin. To understand the inadequately high glucagon levels that contribute to hyperglycemia in type-2 diabetes (T2D), we analyzed granule behavior...
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Full title
Paracrine control of α-cell glucagon exocytosis is compromised in human type-2 diabetes
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TN_cdi_doaj_primary_oai_doaj_org_article_e632b127eee5439face77166a636f601
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_e632b127eee5439face77166a636f601
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-15717-8
