Antibody-directed evolution reveals a mechanism for enhanced neutralization at the HIV-1 fusion pept...
Antibody-directed evolution reveals a mechanism for enhanced neutralization at the HIV-1 fusion peptide site
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Author / Creator
Argonne National Laboratory (ANL), Argonne, IL (United States). Advanced Photon Source (APS) , Banach, Bailey B. , Pletnev, Sergei , Olia, Adam S. , Xu, Kai , Zhang, Baoshan , Rawi, Reda , Bylund, Tatsiana , Doria-Rose, Nicole A. , Nguyen, Thuy Duong , Fahad, Ahmed S. , Lee, Myungjin , Lin, Bob C. , Liu, Tracy , Louder, Mark K. , Madan, Bharat , McKee, Krisha , O’Dell, Sijy , Sastry, Mallika , Schön, Arne , Bui, Natalie , Shen, Chen-Hsiang , Wolfe, Jacy R. , Chuang, Gwo-Yu , Mascola, John R. , Kwong, Peter D. and DeKosky, Brandon J.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
The HIV-1 fusion peptide (FP) represents a promising vaccine target, but global FP sequence diversity among circulating strains has limited anti-FP antibodies to ~60% neutralization breadth. Here we evolve the FP-targeting antibody VRC34.01 in vitro to enhance FP-neutralization using site saturation mutagenesis and yeast display. Successive rounds...
Alternative Titles
Full title
Antibody-directed evolution reveals a mechanism for enhanced neutralization at the HIV-1 fusion peptide site
Authors, Artists and Contributors
Author / Creator
Banach, Bailey B.
Pletnev, Sergei
Olia, Adam S.
Xu, Kai
Zhang, Baoshan
Rawi, Reda
Bylund, Tatsiana
Doria-Rose, Nicole A.
Nguyen, Thuy Duong
Fahad, Ahmed S.
Lee, Myungjin
Lin, Bob C.
Liu, Tracy
Louder, Mark K.
Madan, Bharat
McKee, Krisha
O’Dell, Sijy
Sastry, Mallika
Schön, Arne
Bui, Natalie
Shen, Chen-Hsiang
Wolfe, Jacy R.
Chuang, Gwo-Yu
Mascola, John R.
Kwong, Peter D.
DeKosky, Brandon J.
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Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_e636e8ff307e4e158f7f9667c39522e1
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_e636e8ff307e4e158f7f9667c39522e1
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-023-42098-5
