Glutamine synthetase limits β-catenin-mutated liver cancer growth by maintaining nitrogen homeostasi...
Glutamine synthetase limits β-catenin-mutated liver cancer growth by maintaining nitrogen homeostasis and suppressing mTORC1
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United States: American Society for Clinical Investigation
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Language
English
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Publisher
United States: American Society for Clinical Investigation
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Contents
Glutamine synthetase (GS) catalyzes de novo synthesis of glutamine that facilitates cancer cell growth. In the liver, GS functions next to the urea cycle to remove ammonia waste. As a dysregulated urea cycle is implicated in cancer development, the impact of GS's ammonia clearance function has not been explored in cancer. Here, we show that oncogen...
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Full title
Glutamine synthetase limits β-catenin-mutated liver cancer growth by maintaining nitrogen homeostasis and suppressing mTORC1
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TN_cdi_doaj_primary_oai_doaj_org_article_e6e32c682ad14bdb96a55a2eddeab428
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_e6e32c682ad14bdb96a55a2eddeab428
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ISSN
1558-8238,0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI161408
