Highly active enzymes by automated combinatorial backbone assembly and sequence design
Highly active enzymes by automated combinatorial backbone assembly and sequence design
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Automated design of enzymes with wild-type-like catalytic properties has been a long-standing but elusive goal. Here, we present a general, automated method for enzyme design through combinatorial backbone assembly. Starting from a set of homologous yet structurally diverse enzyme structures, the method assembles new backbone combinations and uses...
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Highly active enzymes by automated combinatorial backbone assembly and sequence design
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TN_cdi_doaj_primary_oai_doaj_org_article_e6f62792433646fab21959e1b02b0675
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_e6f62792433646fab21959e1b02b0675
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-05205-5
