Engineering cell sensing and responses using a GPCR-coupled CRISPR-Cas system
Engineering cell sensing and responses using a GPCR-coupled CRISPR-Cas system
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
G-protein-coupled receptors (GPCRs) are the largest and most diverse group of membrane receptors in eukaryotes and detect a wide array of cues in the human body. Here we describe a molecular device that couples CRISPR-dCas9 genome regulation to diverse natural and synthetic extracellular signals via GPCRs. We generate alternative architectures for...
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Full title
Engineering cell sensing and responses using a GPCR-coupled CRISPR-Cas system
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TN_cdi_doaj_primary_oai_doaj_org_article_e70108db447c4b069358555aee209a1d
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_e70108db447c4b069358555aee209a1d
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-017-02075-1
