Proinsulin misfolding is an early event in the progression to type 2 diabetes
Proinsulin misfolding is an early event in the progression to type 2 diabetes
About this item
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Publisher
England: eLife Science Publications, Ltd
Journal title
Language
English
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Publisher
England: eLife Science Publications, Ltd
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Scope and Contents
Contents
Biosynthesis of insulin - critical to metabolic homeostasis - begins with folding of the proinsulin precursor, including formation of three evolutionarily conserved intramolecular disulfide bonds. Remarkably, normal pancreatic islets contain a subset of proinsulin molecules bearing at least one free cysteine thiol. In human (or rodent) islets with...
Alternative Titles
Full title
Proinsulin misfolding is an early event in the progression to type 2 diabetes
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TN_cdi_doaj_primary_oai_doaj_org_article_e7a8653824104c16932bbe4cb7da543b
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_e7a8653824104c16932bbe4cb7da543b
Other Identifiers
ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.44532
