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Pharmacological inhibition of GRK2 improves cardiac metabolism and function in experimental heart fa...

Pharmacological inhibition of GRK2 improves cardiac metabolism and function in experimental heart fa...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_e81b5044fb7e45569835835d35abf720

Pharmacological inhibition of GRK2 improves cardiac metabolism and function in experimental heart failure

About this item

Full title

Pharmacological inhibition of GRK2 improves cardiac metabolism and function in experimental heart failure

Publisher

England: John Wiley & Sons, Inc

Journal title

ESC Heart Failure, 2020-08, Vol.7 (4), p.1571-1584

Language

English

Formats

Publication information

Publisher

England: John Wiley & Sons, Inc

More information

Scope and Contents

Contents

Aims
The effects of GRK2 inhibition on myocardial metabolism in heart failure (HF) are unchartered. In this work, we evaluated the impact of pharmacological inhibition of GRK2 by a cyclic peptide, C7, on metabolic, biochemical, and functional phenotypes in experimental HF.
Methods and results
C7 was initially tested on adult mice ventricul...

Alternative Titles

Full title

Pharmacological inhibition of GRK2 improves cardiac metabolism and function in experimental heart failure

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_e81b5044fb7e45569835835d35abf720

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_e81b5044fb7e45569835835d35abf720

Other Identifiers

ISSN

2055-5822

E-ISSN

2055-5822

DOI

10.1002/ehf2.12706

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