The molecular basis of JAK/STAT inhibition by SOCS1
The molecular basis of JAK/STAT inhibition by SOCS1
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
The SOCS family of proteins are negative-feedback inhibitors of signalling induced by cytokines that act via the JAK/STAT pathway. SOCS proteins can act as ubiquitin ligases by recruiting Cullin5 to ubiquitinate signalling components; however, SOCS1, the most potent member of the family, can also inhibit JAK directly. Here we determine the structur...
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Full title
The molecular basis of JAK/STAT inhibition by SOCS1
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TN_cdi_doaj_primary_oai_doaj_org_article_e82cd8b59644469288505cb69474018c
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_e82cd8b59644469288505cb69474018c
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-04013-1
