The CCR4–NOT deadenylase complex safeguards thymic positive selection by down-regulating aberrant pr...
The CCR4–NOT deadenylase complex safeguards thymic positive selection by down-regulating aberrant pro-apoptotic gene expression
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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A repertoire of T cells with diverse antigen receptors is selected in the thymus. However, detailed mechanisms underlying this thymic positive selection are not clear. Here we show that the CCR4-NOT complex limits expression of specific genes through deadenylation of mRNA poly(A) tails, enabling positive selection. Specifically, the CCR4-NOT comple...
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Full title
The CCR4–NOT deadenylase complex safeguards thymic positive selection by down-regulating aberrant pro-apoptotic gene expression
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TN_cdi_doaj_primary_oai_doaj_org_article_e8632bde18164a9fa0e055cc88ae0bea
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_e8632bde18164a9fa0e055cc88ae0bea
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-19975-4
