Funnel metadynamics and behavioral studies reveal complex effect of D2AAK1 ligand on anxiety-like pr...
Funnel metadynamics and behavioral studies reveal complex effect of D2AAK1 ligand on anxiety-like processes
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Author / Creator
Bartuzi, Damian , Kędzierska, Ewa , Targowska-Duda, Katarzyna M. , Koszła, Oliwia , Wróbel, Tomasz M. , Jademyr, Simon , Karcz, Tadeusz , Szczepańska, Katarzyna , Stępnicki, Piotr , Wronikowska-Denysiuk, Olga , Biała, Grażyna , Handzlik, Jadwiga , Kristensen, Jesper L. , Poso, Antti and Kaczor, Agnieszka A.
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London: Nature Publishing Group UK
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English
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Publisher
London: Nature Publishing Group UK
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Contents
Anxiety is a troublesome symptom for many patients, especially those suffering from schizophrenia. Its regulation involves serotonin receptors, targeted e.g. by antipsychotics or psychedelics such as LSD. 5-HT
2A
receptors are known for an extremely long LSD residence time, enabling minute doses to exert a long-lasting effect. In this work, w...
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Full title
Funnel metadynamics and behavioral studies reveal complex effect of D2AAK1 ligand on anxiety-like processes
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TN_cdi_doaj_primary_oai_doaj_org_article_e8d54c16692c4f768e6532bff908e43f
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_e8d54c16692c4f768e6532bff908e43f
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-022-25478-7
