Intracellular delivery of protein drugs with an autonomously lysing bacterial system reduces tumor g...
Intracellular delivery of protein drugs with an autonomously lysing bacterial system reduces tumor growth and metastases
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Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Critical cancer pathways often cannot be targeted because of limited efficiency crossing cell membranes. Here we report the development of a Salmonella-based intracellular delivery system to address this challenge. We engineer genetic circuits that (1) activate the regulator
flhDC
to drive invasion and (2) induce lysis to release proteins int...
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Full title
Intracellular delivery of protein drugs with an autonomously lysing bacterial system reduces tumor growth and metastases
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TN_cdi_doaj_primary_oai_doaj_org_article_e8eca79a91024002a55851a8991f0340
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_e8eca79a91024002a55851a8991f0340
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-26367-9
