Linker histone epitopes are hidden by in situ higher-order chromatin structure
Linker histone epitopes are hidden by in situ higher-order chromatin structure
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Publisher
England: BioMed Central Ltd
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Language
English
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Publisher
England: BioMed Central Ltd
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Histone H1 is the most mobile histone in the cell nucleus. Defining the positions of H1 on chromatin in situ, therefore, represents a challenge. Immunoprecipitation of formaldehyde-fixed and sonicated chromatin, followed by DNA sequencing (xChIP-seq), is traditionally the method for mapping histones onto DNA elements. But since sonication fragmenta...
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Full title
Linker histone epitopes are hidden by in situ higher-order chromatin structure
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TN_cdi_doaj_primary_oai_doaj_org_article_e8fa3357252f4bce8207ca41f55bfdd3
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_e8fa3357252f4bce8207ca41f55bfdd3
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ISSN
1756-8935
E-ISSN
1756-8935
DOI
10.1186/s13072-020-00345-9
