Engineering an autonomous VH domain to modulate intracellular pathways and to interrogate the eIF4F...
Engineering an autonomous VH domain to modulate intracellular pathways and to interrogate the eIF4F complex
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Author / Creator
Frosi, Yuri , Lin, Yen-Chu , Shimin, Jiang , Ramlan, Siti Radhiah , Hew, Kelly , Engman, Alf Henrik , Pillai, Anil , Yeung, Kit , Cheng, Yue Xiang , Cornvik, Tobias , Nordlund, Par , Goh, Megan , Lama, Dilraj , Gates, Zachary P. , Verma, Chandra S. , Thean, Dawn , Lane, David P. , Asial, Ignacio and Brown, Christopher J.
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
An attractive approach to target intracellular macromolecular interfaces and to model putative drug interactions is to design small high-affinity proteins. Variable domains of the immunoglobulin heavy chain (VH domains) are ideal miniproteins, but their development has been restricted by poor intracellular stability and expression. Here we show tha...
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Full title
Engineering an autonomous VH domain to modulate intracellular pathways and to interrogate the eIF4F complex
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TN_cdi_doaj_primary_oai_doaj_org_article_e93e759ee68a4352930b901a4ebc4c2b
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_e93e759ee68a4352930b901a4ebc4c2b
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-022-32463-1
