Molecular insights into the α6β4 nicotinic acetylcholine receptor function and ligand recognition
Molecular insights into the α6β4 nicotinic acetylcholine receptor function and ligand recognition
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Author / Creator
Su, Jiawei , Yu, Zhuoya , Yin, Zhengji , Zhang, Zixuan , Zhao, Jun , Meng, Yufei , Li, Renjie , Gao, Yiwei , Zhang, Hongwei , Yu, Rilei and Zhao, Yan
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
The α6β4 nicotinic acetylcholine receptor (nAChR) is found in the sensory neurons of dorsal root ganglia. It is a promising therapeutic target for pain. However, the difficultly of heterologous functional expression of α6β4 receptor has hindered the discovery of drugs that target it. Here, we functionally express the human α6β4 receptor and determi...
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Full title
Molecular insights into the α6β4 nicotinic acetylcholine receptor function and ligand recognition
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TN_cdi_doaj_primary_oai_doaj_org_article_e941b733755649e3ad22c9706f8cbe4d
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_e941b733755649e3ad22c9706f8cbe4d
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-025-58333-0
