PD-1 blockade potentiates HIV latency reversal ex vivo in CD4+ T cells from ART-suppressed individua...
PD-1 blockade potentiates HIV latency reversal ex vivo in CD4+ T cells from ART-suppressed individuals
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
HIV persists in latently infected CD4
+
T cells during antiretroviral therapy (ART). Immune checkpoint molecules, including PD-1, are preferentially expressed at the surface of persistently infected cells. However, whether PD-1 plays a functional role in HIV latency and reservoir persistence remains unknown. Using CD4
+
T cells from HIV...
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Full title
PD-1 blockade potentiates HIV latency reversal ex vivo in CD4+ T cells from ART-suppressed individuals
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TN_cdi_doaj_primary_oai_doaj_org_article_e996a4e085b845f09a6cdde3b15c9886
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_e996a4e085b845f09a6cdde3b15c9886
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-08798-7
