Sirt6 deficiency exacerbates podocyte injury and proteinuria through targeting Notch signaling
Sirt6 deficiency exacerbates podocyte injury and proteinuria through targeting Notch signaling
About this item
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Author / Creator
Liu, Min , Liang, Kaili , Zhen, Junhui , Zhou, Meng , Wang, Xiaojie , Wang, Ziying , Wei, Xinbing , Zhang, Yan , Sun, Yu , Zhou, Zhuanli , Su, Hua , Zhang, Chun , Li, Ningjun , Gao, Chengjiang , Peng, Jun and Yi, Fan
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Podocyte injury is a major determinant of proteinuric kidney disease and the identification of potential therapeutic targets for preventing podocyte injury has clinical importance. Here, we show that histone deacetylase Sirt6 protects against podocyte injury through epigenetic regulation of Notch signaling. Sirt6 is downregulated in renal biopsies...
Alternative Titles
Full title
Sirt6 deficiency exacerbates podocyte injury and proteinuria through targeting Notch signaling
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_e9bf4989decc4c6c98bc0fee37feaa6d
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_e9bf4989decc4c6c98bc0fee37feaa6d
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-017-00498-4
