Synaptic FUS accumulation triggers early misregulation of synaptic RNAs in a mouse model of ALS
Synaptic FUS accumulation triggers early misregulation of synaptic RNAs in a mouse model of ALS
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Mutations disrupting the nuclear localization of the RNA-binding protein FUS characterize a subset of amyotrophic lateral sclerosis patients (ALS-FUS). FUS regulates nuclear RNAs, but its role at the synapse is poorly understood. Using super-resolution imaging we determined that the localization of FUS within synapses occurs predominantly near the...
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Synaptic FUS accumulation triggers early misregulation of synaptic RNAs in a mouse model of ALS
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TN_cdi_doaj_primary_oai_doaj_org_article_e9c043534e61495b8e1dfb249245ca1e
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_e9c043534e61495b8e1dfb249245ca1e
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2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-23188-8
