A novel enhancer regulates MGMT expression and promotes temozolomide resistance in glioblastoma
A novel enhancer regulates MGMT expression and promotes temozolomide resistance in glioblastoma
About this item
Full title
Author / Creator
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Temozolomide (TMZ) was used for the treatment of glioblastoma (GBM) for over a decade, but its treatment benefits are limited by acquired resistance, a process that remains incompletely understood. Here we report that an enhancer, located between the promoters of marker of proliferation Ki67 (
MKI67
) and O6-methylguanine-DNA-methyltransferas...
Alternative Titles
Full title
A novel enhancer regulates MGMT expression and promotes temozolomide resistance in glioblastoma
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_e9cbaa57340b40429d4d685a036a322c
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_e9cbaa57340b40429d4d685a036a322c
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-05373-4
