A TFEB nuclear export signal integrates amino acid supply and glucose availability
A TFEB nuclear export signal integrates amino acid supply and glucose availability
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Publisher
London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Contents
How cells coordinate the response to fluctuating carbon and nitrogen availability required to maintain effective homeostasis is a key issue. Amino acid limitation that inactivates mTORC1 promotes de-phosphorylation and nuclear translocation of Transcription Factor EB (TFEB), a key transcriptional regulator of lysosome biogenesis and autophagy that...
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Full title
A TFEB nuclear export signal integrates amino acid supply and glucose availability
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TN_cdi_doaj_primary_oai_doaj_org_article_e9d8aa256d4f4d8c979b588562b4a5e7
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_e9d8aa256d4f4d8c979b588562b4a5e7
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-04849-7
