Purine nucleoside phosphorylase deficiency induces p53-mediated intrinsic apoptosis in human induced...
Purine nucleoside phosphorylase deficiency induces p53-mediated intrinsic apoptosis in human induced pluripotent stem cell-derived neurons
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Purine nucleoside phosphorylase (PNP) is an important enzyme in the purine degradation and salvage pathway. PNP deficiency results in marked T lineage lymphopenia and severe immunodeficiency. Additionally, PNP-deficient patients and mice suffer from diverse non-infectious neurological abnormalities of unknown etiology. To further investigate the ca...
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Purine nucleoside phosphorylase deficiency induces p53-mediated intrinsic apoptosis in human induced pluripotent stem cell-derived neurons
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TN_cdi_doaj_primary_oai_doaj_org_article_ea144a7cc5a540f8acdc8dcc639a1e1f
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_ea144a7cc5a540f8acdc8dcc639a1e1f
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-022-10935-0
