Bulk cell density and Wnt/TGFbeta signalling regulate mesendodermal patterning of human pluripotent...
Bulk cell density and Wnt/TGFbeta signalling regulate mesendodermal patterning of human pluripotent stem cells
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Author / Creator
Kempf, Henning , Olmer, Ruth , Haase, Alexandra , Franke, Annika , Bolesani, Emiliano , Schwanke, Kristin , Robles-Diaz, Diana , Coffee, Michelle , Göhring, Gudrun , Dräger, Gerald , Pötz, Oliver , Joos, Thomas , Martinez-Hackert, Erik , Haverich, Axel , Buettner, Falk F. R. , Martin, Ulrich and Zweigerdt, Robert
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
In vitro
differentiation of human pluripotent stem cells (hPSCs) recapitulates early aspects of human embryogenesis, but the underlying processes are poorly understood and controlled. Here we show that modulating the bulk cell density (BCD: cell number per culture volume) deterministically alters anteroposterior patterning of primitive streak (P...
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Full title
Bulk cell density and Wnt/TGFbeta signalling regulate mesendodermal patterning of human pluripotent stem cells
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_ea239ac1a9674180890cc009aad95741
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_ea239ac1a9674180890cc009aad95741
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms13602
