Loss of MeCP2 disrupts cell autonomous and autocrine BDNF signaling in mouse glutamatergic neurons
Loss of MeCP2 disrupts cell autonomous and autocrine BDNF signaling in mouse glutamatergic neurons
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England: eLife Science Publications, Ltd
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English
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England: eLife Science Publications, Ltd
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Mutations in the
gene cause the neurodevelopmental disorder Rett syndrome (RTT). Previous studies have shown that altered MeCP2 levels result in aberrant neurite outgrowth and glutamatergic synapse formation. However, causal molecular mechanisms are not well understood since MeCP2 is known to regulate transcription of a wide range of target gene...
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Loss of MeCP2 disrupts cell autonomous and autocrine BDNF signaling in mouse glutamatergic neurons
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TN_cdi_doaj_primary_oai_doaj_org_article_eaa0f71ce81f47009aafd08b447f1eb0
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_eaa0f71ce81f47009aafd08b447f1eb0
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.19374
