Pharmacokinetic Drug Interaction Study of Sorafenib and Morphine in Rats
Pharmacokinetic Drug Interaction Study of Sorafenib and Morphine in Rats
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Publisher
Switzerland: MDPI AG
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Language
English
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Publisher
Switzerland: MDPI AG
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Contents
A combination of the tyrosine kinase inhibitor-sorafenib-and the opioid analgesic-morphine-can be found in the treatment of cancer patients. Since both are substrates of P-glycoprotein (P-gp), and sorafenib is also an inhibitor of P-gp, their co-administration may affect their pharmacokinetics, and thus the safety and efficacy of cancer therapy. Th...
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Full title
Pharmacokinetic Drug Interaction Study of Sorafenib and Morphine in Rats
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TN_cdi_doaj_primary_oai_doaj_org_article_eab7ca12e6b04047a2d2383652c3f609
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_eab7ca12e6b04047a2d2383652c3f609
Other Identifiers
ISSN
1999-4923
E-ISSN
1999-4923
DOI
10.3390/pharmaceutics13122172
