Metformin prevents methylglyoxal-induced apoptosis by suppressing oxidative stress in vitro and in v...
Metformin prevents methylglyoxal-induced apoptosis by suppressing oxidative stress in vitro and in vivo
About this item
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Author / Creator
Wang, Gang , Wang, Yanan , Yang, Qinzhi , Xu, Chunrong , Zheng, Youkun , Wang, Liqun , Wu, Jianbo , Zeng, Min and Luo, Mao
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Methylglyoxal (MGO) is an active metabolite of glucose and plays a prominent role in the pathogenesis of diabetic vascular complications, including endothelial cell apoptosis induced by oxidative stress. Metformin (MET), a widely prescribed antidiabetic agent, appears to reduce excessive reactive oxygen species (ROS) generation and limit cell apopt...
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Full title
Metformin prevents methylglyoxal-induced apoptosis by suppressing oxidative stress in vitro and in vivo
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Author / Creator
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_eabd5c11138148308a2ee3cefc751f5f
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_eabd5c11138148308a2ee3cefc751f5f
Other Identifiers
ISSN
2041-4889
E-ISSN
2041-4889
DOI
10.1038/s41419-021-04478-x
