Glucocorticoid activation by HSD11B1 limits T cell-driven interferon signaling and response to PD-1...
Glucocorticoid activation by HSD11B1 limits T cell-driven interferon signaling and response to PD-1 blockade in melanoma
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Author / Creator
Martins Nascentes Melo, Luiza , Herrera-Rios, Dayana , Hinze, Daniel , Löffek, Stefanie , Oezel, Irem , Turiello, Roberta , Klein, Juliane , Leonardelli, Sonia , Westedt, Isa-Vanessa , Al-Matary, Yahya , Egea-Rodriguez, Sara , Brenzel, Alexandra , Bau, Maja , Sucker, Antje , Hadaschik, Eva , Wirsdörfer, Florian , Hanenberg, Helmut , Uhlenbrock, Niklas , Rauh, Daniel , Poźniak, Joanna , Rambow, Florian , Marine, Jean-Christophe , Effern, Maike , Glodde, Nicole , Schadendorf, Dirk , Jablonska, Jadwiga , Hölzel, Michael and Helfrich, Iris
Publisher
England: BMJ Publishing Group Ltd
Journal title
Language
English
Formats
Publication information
Publisher
England: BMJ Publishing Group Ltd
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More information
Scope and Contents
Contents
BackgroundImmune responses against tumors are subject to negative feedback regulation. Immune checkpoint inhibitors (ICIs) blocking Programmed cell death protein 1 (PD-1), a receptor expressed on T cells, or its ligand PD-L1 have significantly improved the treatment of cancer, in particular malignant melanoma. Nevertheless, responses and durability...
Alternative Titles
Full title
Glucocorticoid activation by HSD11B1 limits T cell-driven interferon signaling and response to PD-1 blockade in melanoma
Authors, Artists and Contributors
Author / Creator
Herrera-Rios, Dayana
Hinze, Daniel
Löffek, Stefanie
Oezel, Irem
Turiello, Roberta
Klein, Juliane
Leonardelli, Sonia
Westedt, Isa-Vanessa
Al-Matary, Yahya
Egea-Rodriguez, Sara
Brenzel, Alexandra
Bau, Maja
Sucker, Antje
Hadaschik, Eva
Wirsdörfer, Florian
Hanenberg, Helmut
Uhlenbrock, Niklas
Rauh, Daniel
Poźniak, Joanna
Rambow, Florian
Marine, Jean-Christophe
Effern, Maike
Glodde, Nicole
Schadendorf, Dirk
Jablonska, Jadwiga
Hölzel, Michael
Helfrich, Iris
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_eb05894568da4d9e909a3aa7f4f8edb4
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_eb05894568da4d9e909a3aa7f4f8edb4
Other Identifiers
ISSN
2051-1426
E-ISSN
2051-1426
DOI
10.1136/jitc-2021-004150
