A Histidine pH sensor regulates activation of the Ras-specific guanine nucleotide exchange factor Ra...
A Histidine pH sensor regulates activation of the Ras-specific guanine nucleotide exchange factor RasGRP1
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England: eLife Science Publications, Ltd
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English
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England: eLife Science Publications, Ltd
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RasGRPs are guanine nucleotide exchange factors that are specific for Ras or Rap, and are important regulators of cellular signaling. Aberrant expression or mutation of RasGRPs results in disease. An analysis of RasGRP1 SNP variants led to the conclusion that the charge of His 212 in RasGRP1 alters signaling activity and plasma membrane recruitment...
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A Histidine pH sensor regulates activation of the Ras-specific guanine nucleotide exchange factor RasGRP1
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TN_cdi_doaj_primary_oai_doaj_org_article_eb4cfd3a6e2c44f5a12f16bff72ec2d2
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_eb4cfd3a6e2c44f5a12f16bff72ec2d2
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.29002
