Comprehensive analysis of DNA damage repair genes reveals pathogenic variants beyond BRCA and sugges...
Comprehensive analysis of DNA damage repair genes reveals pathogenic variants beyond BRCA and suggests the need for extensive genetic testing in pancreatic cancer
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Author / Creator
Rapposelli, Ilario Giovanni , Zampiga, Valentina , Cangini, Ilaria , Arcangeli, Valentina , Ravegnani, Mila , Valgiusti, Martina , Pini, Sara , Tamberi, Stefano , Bartolini, Giulia , Passardi, Alessandro , Martinelli, Giovanni , Calistri, Daniele , Frassineti, Giovanni Luca , Falcini, Fabio and Danesi, Rita
Publisher
England: BioMed Central Ltd
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Language
English
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Publisher
England: BioMed Central Ltd
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Contents
Pancreatic cancer (PC) is a major cause of cancer death. In an effort to improve treatment strategies and outcomes, DNA damage repair (DDR) pathways have been introduced as a new target in PC and in other cancers, through the exploitation of synthetic lethality. Furthermore, genes involved in DDR are among the major determinants of cancer susceptib...
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Full title
Comprehensive analysis of DNA damage repair genes reveals pathogenic variants beyond BRCA and suggests the need for extensive genetic testing in pancreatic cancer
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TN_cdi_doaj_primary_oai_doaj_org_article_eb588727dceb41739f721cc956da76f5
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_eb588727dceb41739f721cc956da76f5
Other Identifiers
ISSN
1471-2407
E-ISSN
1471-2407
DOI
10.1186/s12885-021-08368-5
