Computational Insights into the Structural Dynamics of MDA5 Variants Associated with Aicardi–Goutièr...
Computational Insights into the Structural Dynamics of MDA5 Variants Associated with Aicardi–Goutières Syndrome and Singleton–Merten Syndrome
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Basel: MDPI AG
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English
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Basel: MDPI AG
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Contents
Melanoma differentiation-associated protein 5 (MDA5) is a crucial RIG-I-like receptor RNA helicase enzyme encoded by IFIH1 in humans. Single nucleotide polymorphisms in the IFIH1 results in fatal genetic disorders such as Aicardi–Goutières syndrome and Singleton–Merten syndrome, and in increased risk of type I diabetes in humans. In this study, we...
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Full title
Computational Insights into the Structural Dynamics of MDA5 Variants Associated with Aicardi–Goutières Syndrome and Singleton–Merten Syndrome
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TN_cdi_doaj_primary_oai_doaj_org_article_eb7f902a8dd74fe4926e022ea4270add
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_eb7f902a8dd74fe4926e022ea4270add
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ISSN
2218-273X
E-ISSN
2218-273X
DOI
10.3390/biom11081251
