Carboxylic Acid Bioisosteres in Medicinal Chemistry: Synthesis and Properties
Carboxylic Acid Bioisosteres in Medicinal Chemistry: Synthesis and Properties
About this item
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Publisher
New York: Hindawi
Journal title
Language
English
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Publisher
New York: Hindawi
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Scope and Contents
Contents
Lead optimization represents the tedious process of fine-tuning lead compounds from biologically active hits to suitable drug candidates for clinical trials. By chemically modifying a hit structure, an improved compound can be obtained in terms of activity, selectivity, and pharmacokinetic ADME (absorption, distribution, metabolism, and excretion)...
Alternative Titles
Full title
Carboxylic Acid Bioisosteres in Medicinal Chemistry: Synthesis and Properties
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TN_cdi_doaj_primary_oai_doaj_org_article_eb869c0ebaac4e67ad6db4ac4c90d702
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_eb869c0ebaac4e67ad6db4ac4c90d702
Other Identifiers
ISSN
2090-9063
E-ISSN
2090-9071
DOI
10.1155/2022/2164558
