TFPa/HADHA is required for fatty acid beta-oxidation and cardiolipin re-modeling in human cardiomyoc...
TFPa/HADHA is required for fatty acid beta-oxidation and cardiolipin re-modeling in human cardiomyocytes
About this item
Full title
Author / Creator
Miklas, Jason W. , Clark, Elisa , Levy, Shiri , Detraux, Damien , Leonard, Andrea , Beussman, Kevin , Showalter, Megan R. , Smith, Alec T. , Hofsteen, Peter , Yang, Xiulan , Macadangdang, Jesse , Manninen, Tuula , Raftery, Daniel , Madan, Anup , Suomalainen, Anu , Kim, Deok-Ho , Murry, Charles E. , Fiehn, Oliver , Sniadecki, Nathan J. , Wang, Yuliang and Ruohola-Baker, Hannele
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Mitochondrial trifunctional protein deficiency, due to mutations in hydratase subunit A (HADHA), results in sudden infant death syndrome with no cure. To reveal the disease etiology, we generated stem cell-derived cardiomyocytes from HADHA-deficient hiPSCs and accelerated their maturation via an engineered microRNA maturation cocktail that upregula...
Alternative Titles
Full title
TFPa/HADHA is required for fatty acid beta-oxidation and cardiolipin re-modeling in human cardiomyocytes
Authors, Artists and Contributors
Author / Creator
Clark, Elisa
Levy, Shiri
Detraux, Damien
Leonard, Andrea
Beussman, Kevin
Showalter, Megan R.
Smith, Alec T.
Hofsteen, Peter
Yang, Xiulan
Macadangdang, Jesse
Manninen, Tuula
Raftery, Daniel
Madan, Anup
Suomalainen, Anu
Kim, Deok-Ho
Murry, Charles E.
Fiehn, Oliver
Sniadecki, Nathan J.
Wang, Yuliang
Ruohola-Baker, Hannele
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_eb9585b9475b4ec39e5021a1cc4c96fb
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_eb9585b9475b4ec39e5021a1cc4c96fb
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-12482-1
