Development of a Competitive Nutrient-Based T-Cell Immunotherapy Designed to Block the Adaptive Warb...
Development of a Competitive Nutrient-Based T-Cell Immunotherapy Designed to Block the Adaptive Warburg Effect in Acute Myeloid Leukemia
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Publisher
Switzerland: MDPI AG
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Language
English
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Publisher
Switzerland: MDPI AG
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T-cell-based adoptive cell therapies have emerged at the forefront of cancer immunotherapies; however, failed long-term survival and inevitable exhaustion of transplanted T lymphocytes in vivo limits clinical efficacy. Leukemia blasts possess enhanced glycolysis (Warburg effect), exploiting their microenvironment to deprive nutrients (e.g., glucose...
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Development of a Competitive Nutrient-Based T-Cell Immunotherapy Designed to Block the Adaptive Warburg Effect in Acute Myeloid Leukemia
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TN_cdi_doaj_primary_oai_doaj_org_article_ebb1a91ed9ef452bb180d39522240859
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_ebb1a91ed9ef452bb180d39522240859
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ISSN
2227-9059
E-ISSN
2227-9059
DOI
10.3390/biomedicines12102250
