MicroRNA-9 downregulates the ANO1 chloride channel and contributes to cystic fibrosis lung pathology
MicroRNA-9 downregulates the ANO1 chloride channel and contributes to cystic fibrosis lung pathology
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London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Contents
Cystic fibrosis results from reduced cystic fibrosis transmembrane conductance regulator protein activity leading to defective epithelial ion transport. Ca
2+
-activated Cl
−
channels mediate physiological functions independently of cystic fibrosis transmembrane conductance regulator. Anoctamin 1 (ANO1/TMEM16A) was identified as the maj...
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Full title
MicroRNA-9 downregulates the ANO1 chloride channel and contributes to cystic fibrosis lung pathology
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TN_cdi_doaj_primary_oai_doaj_org_article_ebe9c1b9abb94fe688798f585d120b14
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_ebe9c1b9abb94fe688798f585d120b14
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-017-00813-z
