Breast tumors from ATM pathogenic variant carriers display a specific genome-wide DNA methylation pr...
Breast tumors from ATM pathogenic variant carriers display a specific genome-wide DNA methylation profile
About this item
Full title
Author / Creator
Viart, Nicolas M. , Renault, Anne-Laure , Eon-Marchais, Séverine , Jiao, Yue , Fuhrmann, Laetitia , El Houdigui, Sophia Murat , Le Gal, Dorothée , Cavaciuti, Eve , Dondon, Marie-Gabrielle , Beauvallet, Juana , Raynal, Virginie , Stoppa-Lyonnet, Dominique , Vincent-Salomon, Anne , Andrieu, Nadine , Southey, Melissa C. and Lesueur, Fabienne
Publisher
England: BioMed Central Ltd
Journal title
Language
English
Formats
Publication information
Publisher
England: BioMed Central Ltd
Subjects
More information
Scope and Contents
Contents
The ataxia-telangiectasia mutated (ATM) kinase phosphorylates and activates several downstream targets that are essential for DNA damage repair, cell cycle inhibition and apoptosis. Germline biallelic inactivation of the ATM gene causes ataxia-telangiectasia (A-T), and heterozygous pathogenic variant (PV) carriers are at increased risk of cancer, n...
Alternative Titles
Full title
Breast tumors from ATM pathogenic variant carriers display a specific genome-wide DNA methylation profile
Authors, Artists and Contributors
Author / Creator
Renault, Anne-Laure
Eon-Marchais, Séverine
Jiao, Yue
Fuhrmann, Laetitia
El Houdigui, Sophia Murat
Le Gal, Dorothée
Cavaciuti, Eve
Dondon, Marie-Gabrielle
Beauvallet, Juana
Raynal, Virginie
Stoppa-Lyonnet, Dominique
Vincent-Salomon, Anne
Andrieu, Nadine
Southey, Melissa C.
Lesueur, Fabienne
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_ec1ee47d7458464baf16e74d969c3de2
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_ec1ee47d7458464baf16e74d969c3de2
Other Identifiers
ISSN
1465-542X,1465-5411
E-ISSN
1465-542X
DOI
10.1186/s13058-025-01988-w
