Downregulation of miR-130b~301b cluster is mediated by aberrant promoter methylation and impairs cel...
Downregulation of miR-130b~301b cluster is mediated by aberrant promoter methylation and impairs cellular senescence in prostate cancer
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Publisher
England: BioMed Central Ltd
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Language
English
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Publisher
England: BioMed Central Ltd
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Contents
Numerous DNA-damaging cellular stresses, including oncogene activation and DNA-damage response (DDR), may lead to cellular senescence. Previous observations linked microRNA deregulation with altered senescent patterns, prompting us to investigate whether epigenetic repression of microRNAs expression might disrupt senescence in prostate cancer (PCa)...
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Full title
Downregulation of miR-130b~301b cluster is mediated by aberrant promoter methylation and impairs cellular senescence in prostate cancer
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TN_cdi_doaj_primary_oai_doaj_org_article_ec2503942d574539a463f9d0c832b8bc
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_ec2503942d574539a463f9d0c832b8bc
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ISSN
1756-8722
E-ISSN
1756-8722
DOI
10.1186/s13045-017-0415-1
