Discovery of a dual Ras and ARF6 inhibitor from a GPCR endocytosis screen
Discovery of a dual Ras and ARF6 inhibitor from a GPCR endocytosis screen
About this item
Full title
Author / Creator
Giubilaro, Jenna , Schuetz, Doris A. , Stepniewski, Tomasz M. , Namkung, Yoon , Khoury, Etienne , Lara-Márquez, Mónica , Campbell, Shirley , Beautrait, Alexandre , Armando, Sylvain , Radresa, Olivier , Duchaine, Jean , Lamarche-Vane, Nathalie , Claing, Audrey , Selent, Jana , Bouvier, Michel , Marinier, Anne and Laporte, Stéphane A.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Internalization and intracellular trafficking of G protein-coupled receptors (GPCRs) play pivotal roles in cell responsiveness. Dysregulation in receptor trafficking can lead to aberrant signaling and cell behavior. Here, using an endosomal BRET-based assay in a high-throughput screen with the prototypical GPCR angiotensin II type 1 receptor (AT1R)...
Alternative Titles
Full title
Discovery of a dual Ras and ARF6 inhibitor from a GPCR endocytosis screen
Authors, Artists and Contributors
Author / Creator
Schuetz, Doris A.
Stepniewski, Tomasz M.
Namkung, Yoon
Khoury, Etienne
Lara-Márquez, Mónica
Campbell, Shirley
Beautrait, Alexandre
Armando, Sylvain
Radresa, Olivier
Duchaine, Jean
Lamarche-Vane, Nathalie
Claing, Audrey
Selent, Jana
Bouvier, Michel
Marinier, Anne
Laporte, Stéphane A.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_ec44bf6899064e34b2049b207a9e9931
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_ec44bf6899064e34b2049b207a9e9931
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-24968-y
