Targeting senescent cells enhances adipogenesis and metabolic function in old age
Targeting senescent cells enhances adipogenesis and metabolic function in old age
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Publisher
England: eLife Science Publications, Ltd
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Language
English
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Publisher
England: eLife Science Publications, Ltd
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Contents
Senescent cells accumulate in fat with aging. We previously found genetic clearance of senescent cells from progeroid INK-ATTAC mice prevents lipodystrophy. Here we show that primary human senescent fat progenitors secrete activin A and directly inhibit adipogenesis in non-senescent progenitors. Blocking activin A partially restored lipid accumulat...
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Full title
Targeting senescent cells enhances adipogenesis and metabolic function in old age
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TN_cdi_doaj_primary_oai_doaj_org_article_ec852c46c83c4207854436df1e2e57e8
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_ec852c46c83c4207854436df1e2e57e8
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.12997
