Rational design of a protein that binds integrin αvβ3 outside the ligand binding site
Rational design of a protein that binds integrin αvβ3 outside the ligand binding site
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Integrin α
v
β
3
expression is altered in various diseases and has been proposed as a drug target. Here we use a rational design approach to develop a therapeutic protein, which we call ProAgio, that binds to integrin α
v
β
3
outside the classical ligand-binding site. We show ProAgio induces apoptosis of integrin α
v
β...
Alternative Titles
Full title
Rational design of a protein that binds integrin αvβ3 outside the ligand binding site
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TN_cdi_doaj_primary_oai_doaj_org_article_ec9a3560640e457f934555c56eaba610
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_ec9a3560640e457f934555c56eaba610
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms11675
