The clinical drug candidate anle138b binds in a cavity of lipidic α-synuclein fibrils
The clinical drug candidate anle138b binds in a cavity of lipidic α-synuclein fibrils
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Aggregation of amyloidogenic proteins is a characteristic of multiple neurodegenerative diseases. Atomic resolution of small molecule binding to such pathological protein aggregates is of interest for the development of therapeutics and diagnostics. Here we investigate the interaction between α-synuclein fibrils and anle138b, a clinical drug candid...
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The clinical drug candidate anle138b binds in a cavity of lipidic α-synuclein fibrils
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TN_cdi_doaj_primary_oai_doaj_org_article_ed3eab20b6124a5585faf679ec466929
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_ed3eab20b6124a5585faf679ec466929
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-022-32797-w
