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MDGAs are fast-diffusing molecules that delay excitatory synapse development by altering neuroligin...

MDGAs are fast-diffusing molecules that delay excitatory synapse development by altering neuroligin...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_ed4ed58b731048d6a93d60b138a1317d

MDGAs are fast-diffusing molecules that delay excitatory synapse development by altering neuroligin behavior

About this item

Full title

MDGAs are fast-diffusing molecules that delay excitatory synapse development by altering neuroligin behavior

Publisher

England: eLife Sciences Publications Ltd

Journal title

eLife, 2022-05, Vol.11

Language

English

Formats

Publication information

Publisher

England: eLife Sciences Publications Ltd

More information

Scope and Contents

Contents

MDGA molecules can bind neuroligins and interfere with trans-synaptic interactions to neurexins, thereby impairing synapse development. However, the subcellular localization and dynamics of MDGAs, or their specific action mode in neurons remain unclear. Here, surface immunostaining of endogenous MDGAs and single molecule tracking of recombinant MDG...

Alternative Titles

Full title

MDGAs are fast-diffusing molecules that delay excitatory synapse development by altering neuroligin behavior

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_ed4ed58b731048d6a93d60b138a1317d

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_ed4ed58b731048d6a93d60b138a1317d

Other Identifiers

ISSN

2050-084X

E-ISSN

2050-084X

DOI

10.7554/eLife.75233

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