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GLUT3 inhibitor discovery through in silico ligand screening and in vivo validation in eukaryotic ex...

GLUT3 inhibitor discovery through in silico ligand screening and in vivo validation in eukaryotic ex...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_ed5179664a9e4f51a1594dbab4844691

GLUT3 inhibitor discovery through in silico ligand screening and in vivo validation in eukaryotic expression systems

About this item

Full title

GLUT3 inhibitor discovery through in silico ligand screening and in vivo validation in eukaryotic expression systems

Publisher

London: Nature Publishing Group UK

Journal title

Scientific reports, 2022-01, Vol.12 (1), p.1429-1429, Article 1429

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

Subjects

Subjects and topics

More information

Scope and Contents

Contents

The passive transport of glucose and related hexoses in human cells is facilitated by members of the glucose transporter family (GLUT, SLC2 gene family). GLUT3 is a high-affinity glucose transporter primarily responsible for glucose entry in neurons. Changes in its expression have been implicated in neurodegenerative diseases and cancer. GLUT3 inhi...

Alternative Titles

Full title

GLUT3 inhibitor discovery through in silico ligand screening and in vivo validation in eukaryotic expression systems

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_ed5179664a9e4f51a1594dbab4844691

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_ed5179664a9e4f51a1594dbab4844691

Other Identifiers

ISSN

2045-2322

E-ISSN

2045-2322

DOI

10.1038/s41598-022-05383-9

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