GOT1 inhibition promotes pancreatic cancer cell death by ferroptosis
GOT1 inhibition promotes pancreatic cancer cell death by ferroptosis
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Author / Creator
Kremer, Daniel M. , Nelson, Barbara S. , Lin, Lin , Yarosz, Emily L. , Halbrook, Christopher J. , Kerk, Samuel A. , Sajjakulnukit, Peter , Myers, Amy , Thurston, Galloway , Hou, Sean W. , Carpenter, Eileen S. , Andren, Anthony C. , Nwosu, Zeribe C. , Cusmano, Nicholas , Wisner, Stephanie , Mbah, Nneka E. , Shan, Mengrou , Das, Nupur K. , Magnuson, Brian , Little, Andrew C. , Savani, Milan R. , Ramos, Johanna , Gao, Tina , Sastra, Stephen A. , Palermo, Carmine F. , Badgley, Michael A. , Zhang, Li , Asara, John M. , McBrayer, Samuel K. , di Magliano, Marina Pasca , Crawford, Howard C. , Shah, Yatrik M. , Olive, Kenneth P. and Lyssiotis, Costas A.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
Cancer metabolism is rewired to support cell survival in response to intrinsic and environmental stressors. Identification of strategies to target these adaptions is an area of active research. We previously described a cytosolic aspartate aminotransaminase (GOT1)-driven pathway in pancreatic cancer used to maintain redox balance. Here, we sought t...
Alternative Titles
Full title
GOT1 inhibition promotes pancreatic cancer cell death by ferroptosis
Authors, Artists and Contributors
Author / Creator
Nelson, Barbara S.
Lin, Lin
Yarosz, Emily L.
Halbrook, Christopher J.
Kerk, Samuel A.
Sajjakulnukit, Peter
Myers, Amy
Thurston, Galloway
Hou, Sean W.
Carpenter, Eileen S.
Andren, Anthony C.
Nwosu, Zeribe C.
Cusmano, Nicholas
Wisner, Stephanie
Mbah, Nneka E.
Shan, Mengrou
Das, Nupur K.
Magnuson, Brian
Little, Andrew C.
Savani, Milan R.
Ramos, Johanna
Gao, Tina
Sastra, Stephen A.
Palermo, Carmine F.
Badgley, Michael A.
Zhang, Li
Asara, John M.
McBrayer, Samuel K.
di Magliano, Marina Pasca
Crawford, Howard C.
Shah, Yatrik M.
Olive, Kenneth P.
Lyssiotis, Costas A.
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Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_ed8c3b2903a54147ade49ed6c779e8e5
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_ed8c3b2903a54147ade49ed6c779e8e5
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-24859-2
